Arnoud De Meyer talks about the importance of research and development to positively contribute in every country’s economic growth. He explains how investing in science and technology, eventually results in good returns, even though this outcome is not immediate. De Meyer comments on the important role individual entrepreneurs play in innovation and the value of private investment. In the effort to provide a clear understanding, he shares a few lessons learned during his entrepreneurial journey, and advises on finding a “lead user”, who is a consumer of a product or service, currently facing needs that are yet unknown to other users and who, ultimately, will benefit if solutions to such needs are found. He also illustrates several sources of novelty and examples of how products and services have evolved with the aid of platforms, technology and better infrastructure. Finally, De Meyer expresses his perspective on innovation in services and business models, networking, teamwork, and organization.